Ivermectin is used to treat head lice and certain parasitic infections…But for COVID? The WHO, CDC, FDA, and IDSA say it should not be used for COVID….UNLESS… it’s in a clinical trial.
But that didn’t stop this guy, who chose ivermectin over the vaccine…Captain Joe Manning, 57, A Georgia police officer who frequently posted anti-vax messages on Facebook, died of COVID. Why would some people want a drug that is not FDA approved for COVID, because it has not been proven to be effective, and has not been proven to be safe…..why would someone choose that over something that has been proven to be safe and effective in preventing COVID?
Whenever we put something into our body, whether that is drinking something, eating something, taking a pill, or getting a jab….It’s important to know 3 things…
1) Does it work?
2) Is it safe?
3) At what dose does it work, and at what dose is it safe
For example, dihydrogen monoxide. That’s not something you want to ingest TOO much of. Why? Because it can cause severe hyponatremia, which leads to brain swelling, and I’ve seen people die in this manner.
But….on the other hand, we can’t live without ingesting dihydrogen monoxide….also known as water. Generally, we should drink 10-14 cups per day, depending on various factors. So, of course, we need water. But do we need ivermectin…..for COVID? I WISH it were the miracle drug. I wish we could have a cheap, safe, and effective drug that fights the virus. Or saves lives my minimizing the cytokine storm in the body, that is brought on by the virus.
Well, we do kind of have that with dexamethasone. AKA decadron, which is a steroid that is very similar to prednisone. It’s the one drug that has the most solid evidence for reducing the severity of COVID illness, including reducing mortality. And its cheap too. But its not a miracle drug.
So how do we know if ivermectin 1) works 2) if so, what dose is required for it to work 3) is that dose safe for ingestion??? The ivermectin hype train left the station back in April of 2020.
It all started with this study that looked at the virus in a test tube, when scientists suffocated the virus with massive doses of ivermectin. And surprise surprise, guess what the results showed? There was major drop in viral replication. And that’s great, right? It’s a starting point. It’s saying, hey, we might have something here. But there’s a problem. The inhibitory concentration of the drug, around 2.5 micromolar, is not achievable in real live humans. In fact, standard ivermectin dosing achieves blood concentrations of about 25 nanomolar, 100-fold less than what was needed in vitro. Lung concentrations are a bit higher than blood concentrations but still 50-fold less than what is needed to inhibit the virus in cells in culture.
But ok, maybe it works not necessarily by inhibiting viral replication, maybe it can help suppress inflammation from COVID.
So you start doing some observational studies. Observational studies are not great studies, but they serve a purpose, because you want to see if there is any correlation between ivermectin and its potential to help against COVID. If you see a correlation there, then that warrants spending more time and money to do a bigger, higher quality study, in order to prove or disprove that the drug is safe and effective. And the best studies for that, are double-blinded, randomized placebo control trials. The more people in the study, the more you can rely on the results. That is how you prove cause and effect.
So you take 30,000 people, you give half of them a placebo, and the other half the medicine. Then you look at your results, and that is how you get your answer, if its safe and effective. That’s the process that was done with the vaccines. The same can not be said for Ivermectin.
Generally speaking, ivermectin, when given doses used to treat parasitic infections…. in humans, is very safe. So we’re talking about 200 mcg per kilogram, so for a 75 kg person, around 165 pounds, you’re looking at a 15 mg dose. Before the pandemic, prescriptions for ivermectin in this country were 3,600 per week. Now they are more than 88,000 per week. But even more concerning is people getting the drug from livestock supply centers, where it can come in a highly concentrated paste or liquid forms? Sometimes 10 to 15 times the amount that we give people.
Well guess what? Mississippi’s health department said that 70% of recent calls to the state poison control center had come from people who ingested ivermectin from livestock supply stores. Same thing going on in Alabama. What are the common symptoms? Nausea, vomiting, diarrhea. But there’s also nerve damage, seizures, and sometimes death.