Reinfection with South African variant

Severe reinfection with South African SARS-CoV-2 variant 501Y.V2: A case report

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab129/6132402

Journal of Clinical Infectious Diseases, 10 February 2021

Reinfections

Rare albeit probably underestimated

Confirmed cases worldwide, 31

In most cases less severe than the initial infection

A case of severe SARS-CoV-2 reinfection with South African variant 501Y.V2

September, mild COVID-19, no genomic sequencing

58-year old immunocompetent male

History of asthma

December, tested negative twice

January 2021, 129 days later, recurrent dyspnea and fever

K417N, E484K and N501Y in RBD

5 others in spike protein

Seven days later, severe acute respiratory distress syndrome

Requiring intubation and mechanical ventilation

SA variant not previously associated with more severe disease

Dexamethasone and tocilizumab

Antibody testing was positive for IgG against SARS-CoV-2

Peru

https://www.aljazeera.com/news/2021/2/15/peru-foreign-minister-resigns-over-covid-vaccine-scandal

Foreign minister, vaccinated last month, resigned

Health Minister, resigned

Early vaccination of senior officials

Hospitals overwhelmed

Health workers rolling, from February 8, 300,000 doses

Australia

Victoria

UK variant, 16 cases

Cluster, workers at a quarantine hotel at Melbourne airport

Five day lockdown

Two new cases of locally transmitted infections, 3 year old

New Zealand

Three unexplained cases

One family

Airline catering laundry worker

Three-day lockdown in Auckland

Japan

Approves BioNTech-Pfizer vaccine

Starting next week

Small sample size of the extra trial

Germany

https://www.dw.com/en/germany-angela-merkel-vows-to-improve-coronavirus-vaccine-rollout-but-warns-of-mutations/a-56556191

disappointment

at full capacity, end of March / April

smart to avoid a third wave, March 7th

UK, Ten day hotel quarantine starts today

https://www.bbc.co.uk/news/uk-56064759

England, red list of 33 countries

Scotland, all international arrivals

£1, 750

£650 for additional adult

Priority groups

Vaccinations

First dose, 15,062,189

Second dose, 537,715

https://coronavirus.data.gov.uk/details/cases

https://www.gov.uk/government/publications/covid-19-vaccination-care-home-and-healthcare-settings-posters/covid-19-vaccination-first-phase-priority-groups

Starting group 5

All those 65 years of age and over

Next, group 6

Adults aged 16 to 65 years in an at-risk group

Excess mortality reveals Covid’s true toll in Russia

https://rss.onlinelibrary.wiley.com/doi/10.1111/1740-9713.01486

1 January 2021, Deaths

Russia 57,600 deaths (0.04% of population)

Peru (0.12%)

Spain (0.11%)

UK (0.11%)

USA (0.11%)

Excess mortality in Russia from April to November

Excess deaths, 264,100

Estimate of excess mortality is 6.5 times than the 40,500 deaths reported

April to November, 0.18% of the country’s population

Ratio of 6.5, largest ratio across all countries

Daily reported death count for Russia, one of the least reliable indicators of epidemiological situation across all countries

By comparison

US, x 1.3

Mexico, x 2.5

Italy, x 1.7

UK, x 1.5

Spain, x 1.4

Iran, x 2.4

Germany, x 1.2

Poland, x 2.9

South Africa, x 2.1

Russia, 14th February 2021

Population, 144 million

Official death figures, 78,825 (JH)

X 6.5 = 512,362

0.35% of population

Source: Dr. John Campbell

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